师资简介—深圳大学物理与光电工程学院

刘丽炜

姓名: 刘丽炜

性别：女

研究方向：生物医学光子学：主要开展非线性光学显微成像和荧光寿命显微成像技术的研发及生物医学应用

职称：教授、研究员

邮箱：liulw@szu.edu.cn

座机：0755-26914992

个人简介

刘丽炜，国家自然科学基金委“杰出青年科学基金”获得者；深圳大学物理与光电工程学院特聘教授；国家自然科学基金委“优秀青年科学基金”获得者。深圳市 “杰出青年”基金获得者，深圳市地方级领军人才，深圳市“孔雀计划”海外高层次C类人才，长期从事光学显微成像技术研究，提出并发展了三项基于非线性光学效应的显微成像新方法和新技术，实现了其在生物医学领域的重要应用。近五年包括Light Sci. Appl, Adv. Sci, Opt. Lett等期刊发表SCI论文83篇；主持/完成国家和省部级项目共15项，所培养的博士生2人次获全国光学与光学工程博士联系华南赛区一等奖，硕士生1人次获院优秀毕业生。兼任《中国光学》编辑委员会青年委员，《中国激光》杂志社青年编辑委员会委员。兼任中国光学学会生物医学光子学专委会副主任委员，中国生物医学工程学会生物医学光子学分会副秘书长、常委。

个人信息

主持项目/课题：
(1) 国家自然科学基金委员会, 面上项目, 62175163, 基于像差校正的双光子荧光寿命光学显微成像技术及其活体成像应用, 2022-01-01 至 2025-12-31, 58万元, 在研, 主持 
(2) 国家自然科学基金委员会, 重点项目, 61935012, 卵巢肿瘤免疫治疗中的微环境光学成像方法研究, 2020-01-01 至 2024-12-31, 295万元, 在研, 主持 
(3) 国家自然科学基金委员会, 国际(地区)合作与交流项目, 61961136005, 镧系掺杂上转换和量子裁剪发光纳米粒子在生物医学中的应用, 2019-07-01 至 2022-06-30, 140万元, 在研, 主持 
(4) 国家自然科学基金委员会, 优秀青年科学基金项目, 61722508, 纳米生物光子学, 2018-01-01 至 2020-12-31, 130万元, 结题, 主持 
(5) 国家科学技术部, 国家重点研发计划, 2021YFF0502900, 多维信息实时获取高分辨显微成像, 2022-04 至 2027-04, 365万元, 在研, 课题负责人
(6) 国家科学技术部, 国家重点研发计划, 2017YFA0700400, 完整肝脏三维结构与功能信息的精准介观测量, 2018-05 至 2023-04, 305万元, 在研, 子课题负责人
(7) 深圳市科技创新委员会,深圳市杰出青年基金项目，RCJC20210706091949022，高分辨双光子荧光寿命光学显微成像研究，2022-04 至 2027-04，400万元，在研，主持
(8) 深圳市科技创新委员会, 重点项目, JCYJ20200109105404067, 基2020N347利用多光谱成像系统开展药物作用机制的研究, 2020-11 至 2023-11, 200万元, 主持 
(9) 深圳市科技创新委员会, 基础研究（自由探索）, JCYJ20180305124902165, 基于纳米探针的脑部肿瘤成像研究, 2019-03 至 2021-03, 50万元, 结题, 主持
论文：
(1) Binglin Shen; Shaowen Liu; Yanping Li; Ying Pan; Yuan Lu; Rui Hu; Junle Qu; Liwei Liu*; Deep learning autofluorescence-harmonic microscopy, Light-Science & Applications, 2022, 11(1): 76. 
(2) Yanping Li; Binglin Shen; Gengjin Zou; Rui Hu; Ying Pan; Junle Qu; Liwei Liu*; Super-Multiplex Nonlinear Optical Imaging Unscrambles the Statistical Complexity of Cancer Subtypes and Tumor Microenvironment, Advanced Science, 2021, 9(5): 2104379 
(3) Yunjian Xu; Shiqi Wang; Zhenjiang Chen; Rui Hu; Yihua Zhao; Kexin Wang; Junle Qu; Liwei Liu*; Nitric oxide release activated near-Infrared photothermal agent for synergistic tumor treatment, Biomaterials, 2020, 276: 121017-1-121017-10 
(4) Wenhui Yu; Xiang Li; Rui Hu; Junle Qu; Liwei Liu*; Full-field measurement of complex objects illuminated by an ultrashort pulse laser using delay-line sweeping off-axis interferometry, Optics Letters, 2021, 46(12): 2803-2806 
(5) Shiqi Wang; Yanping Li; Yihua Zhao; Fangrui Lin; Junle Qu; Liwei Liu*; Investigating tunneling nanotubes in ovarian cancer based on two-photon excitation FLIM-FRET, Biomedical Optics Express, 2021, 12(4): 1962-1973 
(6) Yunjian Xu; Shiqi Wang; Zhenjiang Chen; Rui Hu; Shaoqiang Li; Yihua Zhao; Liwei Liu*; Junle Qu; Highly Stable Organic Photothermal Agent Based on Near-Infrared-II Fluorophores for TumorTreatment, Journal of Nanobiotechnology, 2021, 19(37): 1-14 
(7) Mahmoud AL-Salihi; Rongxing Yi; Shiqi Wang; Qiang Wu; Fangrui Lin; Junle Qu; Liwei Liu*; Quantitative laser-induced breakdown spectroscopy for discriminating neoplastic tissues from nonneoplastic ones, Optics Express, 2021, 29(3): 4159-4173 
(8) Yanping Li; Binglin Shen; Gengjin Zou; Shiqi Wang; Junle Qu; Rui Hu; Liwei Liu*; Fast denoising and lossless spectrum extraction in stimulated Raman scattering microscopy, Journal of Biophotonics, 2021, 14(8): e202100080 
(9) Binglin Shen; Shiqi Wang; Ganapathi Bharathi; Yanping Li; Fangrui Lin; Rui Hu; Liwei Liu*; Junle Qu* ; Rapid and Targeted Photoactivation of Ca2+ Channels Mediated by Squaraine To Regulate Intracellular and Intercellular Signaling Processes, Analytical Chemistry, 2020, 92: 8497-8505 
(10) Yue Zhao; Siqi Wang; John A. Merrill; Jesus D. Arellano; Luis M. Trevisi; Yizhou Li; Liangzhong Xiang; Junle Qu; Liwei Liu*; Triplex radiometric, photoacoustic, and ultrasonic imaging based on single-pulse excitation, Optics Letters, 2020, 45(7): 1703-1706 
(11) Binglin Shen; Liwei Liu*; Yanping Li; Sheng Ren; Junshuai Yan; Rui Hu; Junle Qu*; Nonlinear Spectral-Imaging Study of Second- and Third-Harmonic Enhancements by Surface-Lattice Resonances, Advanced Optical Materials, 2020, 8: 1901981-1-1901981-7 
(12) Binglin Shen; Junshuai Yan; Shiqi Wang; Feifan Zhou; Yihua Zhao; Rui Hu; Junle Qu*; LiweiLiu*; Label-free whole-colony imaging and metabolic analysis of metastatic pancreatic cancer by an autoregulating flexible optical system, Theranostics, 2020, 10(4): 1849-1860 
(13) Fangrui Lin; Pintu Das; Yihua Zhao; Binglin Shen; Rui Hu; Feifan Zhou; Liwei Liu*; Junle Qu* ; Monitoring the endocytosis of bovine serum albumin based on the fluorescence lifetime of small squaraine dye in living cells, Biomedical Optics Express, 2020, 11(1): 149-159 
(14) Rongxing Yi; Pintu Das; Fangrui Lin; Binglin Shen; Zhigang Yang; Yihua Zhao; Liang Hong; Ying He; Rui Hu; Jun Song; Junle Qu*; Liwei Liu*; Fluorescence enhancement of small squaraine dye and its two-photon excited fluorescence in long-term near-infrared I&II bioimaging, Optics Express, 2019, 27(9): 12360-12372 
(15) Yue Zhao; Shaozhuang Yang; Yating Wang; Zhen Yuan; Junle Qu; Liwei Liu*; In vivo blood viscosity characterization based on frequency-resolved photoacoustic measurement, Applied Physics Letters, 2018, 113: 143703-1-143703-5